A predefined data extraction form was used for the extraction of all relevant information, which included different categories: study characteristics (author ID, country, sample size, dosage, and follow-up duration), patient characteristics (age and gender), outcomes (MACEs, biomarker changes (e.g., IL-6, CRP), and pericarditis resolution), patient-centered metrics (quality of life, adherence, and adverse events), and subgroup analyses (comorbidities, MACEs, all complications, CVD-associated mortality, and all-cause mortality). This evidence concerns the gene IL6 and pericarditis.