IL6 and systemic lupus erythematosus: Recent transcriptomic studies in SLE-associated PH have identified three molecular endotypes: one dominated by IFN/TNF signaling pathways linked to systemic inflammation; a second characterized by elevated IL-6 expression with a more benign hemodynamic profile; and a third defined by dysregulation of vascular smooth muscle genes, associated with greater disease severity and worse prognosis.