This complex transcriptional factor activates groups of tumor-specific genes, such as angiogenic factors vascular endothelial growth factor A (VEGF-A) and platelet-derived growth factor B (PDGF-B) and growth factors transforming growth factor alpha (TGF-α), glucose transporter 1, erythropoietin, and cyclin D1 [17]. This evidence concerns the gene VEGFA and neoplasm.