A significantly high incidence of diabetes mellitus (OR: 2.23; 95% CI: 1.09-4.54), respiratory tract allergies (OR: 1.95; 95% CI: 1.24-3.05), recurrent upper respiratory tract infections (OR: 3.58; 95% CI: 2.29-5.59), past history of dengue (OR: 2.56; 95% CI: 1.04-6.28), urban living (OR: 1.52; 95% CI: 0.84-2.78), active lifestyle (OR: 11.44; 95% CI: 7.50-17.46), along with a rapid reduction in daily platelet (~34%) and white blood cell (WBC) (~25%) counts, and rise of serum alanine transaminase (ALT) (~67%) during the initial few days of fever were detected in DHF cases. The gene discussed is GPT; the disease is Recurrent upper respiratory tract infections.