To clarify the novelty of this study relative to our 2023 preprint (“Long non-coding RNA ZFHX4-AS1 Upregulates the Neural Differentiation-related Gene ZFHX4 and thereby Promotes SOX2 Expression to Accelerate Glioma Progression”), we provide a side-by-side comparison of the core findings. The gene discussed is SOX2; the disease is glioma.