A total of 310 ILD, 3,377 VTE, and 408 QT prolongation reports were found in FAERS, as of January 2024. A disproportionality signal was found for TE and CDK4/6 inhibitors as a class and as individual drugs with Ribociclib (ROR 1.67, 95% CI 1.41-1.99), Abemaciclib (ROR 6.84, 95% CI 6.08-7.71), and Palbociclib (ROR 1.65, 95% CI 1.51-1.81). This evidence concerns the gene CDK4 and interstitial lung disease.