Mechanistic studies revealed that Butein markedly downregulated the protein and mRNA expression of TWEAK, FN14, and TRAF1/2 in tumor tissue, and decreased serum levels of NF-κB-related inflammatory factors, including IL-1β, IL-6, IFN-γ, and TNF-α. The gene discussed is TNFRSF12A; the disease is neoplasm.