Meanwhile, the long non-coding RNA AP001885.4 promotes the expression of c-myc by inducing histone lactylation and NF-κB (p65)-dependent transcriptional activation, enhancing its mRNA stability through METTL3, and ultimately facilitating the proliferation of esophageal squamous cell carcinoma (36). Here, NFKB1 is linked to esophageal squamous cell carcinoma.