demonstrated that the long non-coding RNA AP001885.4 plays a significant role in promoting both the proliferation and invasion of esophageal squamous cell carcinoma (ESCC) cells through the regulation of histone lactylation, transcriptional activation dependent on NF-κB (p65), and the stability of c-myc mRNA mediated by METTL3 (41). Here, METTL3 is linked to esophageal squamous cell carcinoma.