LRRN1 and breast carcinoma: Although LRRN1 overexpression has been previously associated with aggressive gastric cancer phenotypes and poor survival (9), our findings in breast cancer contrast sharply with this: we revealed an inverse correlation between LRRN1 expression and advanced pathological stages/TNM classifications, and survival analyses showed reduced LRRN1 expression significantly increased mortality risk (log-rank p < 0.01)—this tissue-specific difference in LRRN1 function highlights its context-dependent role, which has not been reported in prior LRRN1-related studies.