Importantly, multivariate Cox regression analysis, incorporating established prognostic variables (age, ER/PR/HER2 status, molecular subtype, tumor grade, Ki67 index, and p53 status), confirmed LRRN1 as an independent predictor of DFS (HR = 0.7560, 95% CI: 0.559-0.866, p = 0.001) (Table 3). Here, ESR1 is linked to neoplasm.