The notable discordance observed in our patient between the preoperative biopsy (Ki67 30%) and the final resection specimen (Ki67 60%) underscores several critical considerations: 1) the inherent sampling limitations associated with fragmented biopsies, 2) the significant intratumoral heterogeneity of proliferative activity, and 3) the consequent risk of underestimating the true biological aggressiveness of the tumor when relying solely on local excision techniques. Here, MKI67 is linked to neoplasm.