To test the hypothesis that HMCN1 is a pan-cancer tumor-promoting gene that promotes malignancy primarily through activating EMT, the present study conducted a comprehensive analysis of HMCN1 characteristics across 33 cancer types by integrating data from The Cancer Genome Atlas (TCGA), Genotype-Tissue Expression (GTEx), and DepMap, as well as single-cell and spatial transcriptomic atlases. The gene discussed is HMCN1; the disease is cancer.