We integrated mRNA expression profiles from 10 data platforms comprising a total of 540 cases, including 414 osteosarcoma and 126 non-osteosarcoma cases, and the results showed that HMCN1 mRNA expression was significantly higher in the osteosarcoma group than in the non-osteo-sarcoma group (standardized mean difference = 0.80, 95% CI: 0.47–1.14; p = 0.024) (Figure 6A). Here, HMCN1 is linked to sarcoma.