HMCN1 and neoplasm: Analysis of the relationship between HMCN1 expression levels and the distribution of immune subtypes revealed that in tumors with high HMCN1 expression, the proportion of the C3 subtype (an inflammatory subtype, characterized by high expression of Th17- and Th1-related genes and typically associated with weaker tumor proliferation inhibition) was significantly increased, whereas the proportion of the C5 subtype (an immunologically quiet subtype) was lower (Figure 4A) (25).