Hepatic steatosis and excess visceral adiposity promote the release of pro-inflammatory cytokines—most notably tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and interleukin-1β (IL-1β)—which exert deleterious effects on musculoskeletal tissues (72–76). This evidence concerns the gene IL6 and Hepatic steatosis.