Identified risk factors for bone metastasis are primary tumor diameter greater than 4 cm (Odds Ratio = 3.2), vascular invasion (Hazard Ratio = 4.1), and the co-occurrence of BRAF(v-Raf murine sarcoma viral oncogene homolog B1) and TERT (Telomerase Reverse Transcriptase)promoter mutations (p value = 0.003) (30, 38, 39). This evidence concerns the gene TERT and neoplasm.