Tumor cells (the “seed”) feature SSTR2 (somatostatin receptor 2) (supporting 68Ga-DOTATATE PET/CT [positron emission tomography/computed tomography] detection), BSP (bone sialoprotein) (aiding adhesion/angiogenesis), CgA (chromogranin A) (modulating the bone microenvironment), and oncogenic microRNAs (miR-210, miR-21) that promote BM (14–17). This evidence concerns the gene IBSP and neoplasm.