The same results as in the previous results showed that the expression of RANKL was significantly increased and the expression of OPG was significantly decreased in mice with gut microbiota dysbiosis after antibiotic treatment, and the expression of RANKL/OPG was significantly increased (Figures 5A–C), which suggests that osteoporosis is related to the enhancement of osteoclast activity. This evidence concerns the gene TNFSF11 and osteoporosis.