This seems to synthesize the different results from previous studies, such as those of Shimizu (36) and Zhang (37), who found that Ang II causes osteoporosis through activation of AT1R and by the ERK pathway, and those of Asaba (34), Izu (38) and Monnouchi (39), who confirmed that Ang II is involved in the process of osteoporosis through activation of AT2R involved in the process of osteoporosis. This evidence concerns the gene AGTR1 and osteoporosis.