TNFSF11 and osteoporosis: In conclusion, our study suggests that antibiotic treatment can lead to gut microbiota dysbiosis and activation of local RAS in bone tissue leading to osteoporosis, a process that promotes RANKL release and inflammatory response through upregulation of ERK1/2 expression, upregulation of osteoclast activity leading to bone loss, and that AT2R may be an important target.