PIK3CA and neoplasm: Moreover, recent studies demonstrated that FABP5 and the FTO demethylase stabilize FASN, enhancing lipid accumulation and activating key oncogenic pathways such as WNT/β-catenin and PI3K/AKT/mTOR inhibition of FABP5 or FTO decreased tumor cell proliferation and migration, and the combination of orlistat with everolimus enhanced antitumor effects.