Possible risk factors: gallstones, Clonorchis sinensis infection; Common TP53 and RB1 mutations; other alterations in ERBB4, HRAS, NRG1, HMCN1, and CDH10, fusions of NCAM2::SGCZ and BTG3::CCDC40, and microsatellite instability; no BRAF mutations. The gene discussed is NRG1; the disease is gallstones.