Utilizing multiple stepwise linear regression analysis with serum asprosin as the dependent variable and relevant indicators as independent variables among the population with liver diseases, the study found that TG (β = 24.006, SE = 10.338, t = 2.322, p = 0.023), TCH (β = -24.809, SE = 12.253, t = -2.025, p = 0.046), and PLT (β = 0.405, SE = 0.108, t = 3.738, p < 0.001) were independent influencing factors for serum asprosin (Table 3). This evidence concerns the gene FBN1 and liver disorder.