ALB and nutritional deficiency disease: Although alternative explanations such as dilutional hypoalbuminemia from fluid resuscitation, extravascular redistribution due to capillary leak, exogenous albumin administration, or short-term nutritional deficiency may exist, the synchronous and dose-dependent decline in both PA (half-life 2–3 days) and ALB (half-life 19–21 days) strongly supports a “synthesis inhibition-dominated” mechanism rather than mere distributional abnormalities (34).