Outcomes including serum interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) levels, synovial fluid matrix metalloproteinase-3 (MMP-3) and tissue inhibitor of metalloproteinases-1 (TIMP-1) levels, visual analog scale (VAS) score, Western Ontario and McMaster Universities Arthritis Index (WOMAC) score, Lysholm score and complications were all recorded and compared. The gene discussed is TNF; the disease is Arthritis.