BTK and autoimmune thrombocytopenic purpura: Meta-analysis from these studies revealed that ITP therapy employing SYK and/or BTK inhibitors was associated with lower rate of rescue treatments administration compared to placebo (RR 0.59; 95%CI: 0.47 – 0.73, p<0.00001, I2 = 0%, random-effect model) (Figure 2D) (Table 3).