Combined results from three publications including 386 adult ITP patients showed no significant disparity in the overall incidence of diarrhea between individuals administered SYK and/or BTK inhibitors and those given a placebo (RR 1.95; 95%CI: 0.78 – 4.90, p=0.15, I2 = 57%, random-effect model) (Table 3). This evidence concerns the gene BTK and autoimmune thrombocytopenic purpura.