On the other hand, the study by Jaiswal et al. utilised whole-exome sequencing in large human cohorts to associate specific CHIP gene mutations (DNMT3A, TET2, ASXL1, JAK2) with increased CAD risk, which was further strengthened through experimental in vivo studies in mouse models, which demonstrated that loss of TET2 function results in accelerated atherosclerosis.16 Here, JAK2 is linked to coronary artery disorder.