MMP9 and cancer: We also discovered that glutamate activates directly its GluRs expressed in T cells and induces/increases all these T cell functions and features: integrin-mediated adhesion to laminin and fibronectin, chemotactic migration, elevation of CD147/EMMPRIN (a cancer-associated matrix metalloproteinase (MMP) inducer, MMP-9 secretion, engraftment of cells in vivo, CD3 zeta expression, and most importantly T cell killing of cancer cells (Ganor et al., 2003; Ganor et al., 2009; Ganor and Levite, 2014; Levite et al., 2021; Saussez et al., 2014).