Despite the role of the Ald/MR pathway in the distal nephron and the non-MR Rac1-mediated pathway in the pathogenesis of hypertension and hypokalemia being well-established (Hirohama et al., 2021; Bazard et al., 2020; Shibata et al., 2008), the function of MR and Ald-mediated electrolyte transport in the PTs remains unclear (Salyer et al., 2013; Girard et al., 2003). The gene discussed is NR3C2; the disease is Hypertension.