SLC5A2 and hypophosphatemia: Although TWIK-1 is not exclusively expressed in the PT, in mice, the knockout of TWIK-1/Kcnk1 results in hypophosphatemia owing to impaired phosphate transport in the PT (Nie et al., 2005), suggesting the role of TWIK-1 in the membrane trafficking of transport molecules in PTs and its potential link with SGLT2.