IGFBP2 and severe feeding difficulties-failure to thrive-microcephaly due to ASXL3 deficiency syndrome: Bainbridge–Ropers syndrome (BRPS, OMIM #615485) and the 15q11.2 BP1-BP2 microdeletion syndrome (OMIM #615656) are distinct genetic aetiologies of neurodevelopmental disorder Dual diagnosis of both entities in a single patient is extremely rare, and the underlying synergistic pathogenesis remains poorly understood.