Our patient presented with a compelling clinical picture, including an extraordinarily high NIH-HIES score of 73 points, significantly elevated serum IgE (22,800 IU/mL), recurrent “cold” skin abscesses, pneumatoceles, severe eczematous dermatitis, and characteristic facial features, thereby strongly suggesting STAT3-HIES. Here, STAT3 is linked to Cutaneous abscess.