IGHE and abscess: Her manifestations—recurrent cold abscesses, pneumatoceles, severe eczema, and extreme IgE elevation—closely match the clinical profile of STAT3-DN patients as quantified by Hajjaligol et al., which shows a significantly higher prevalence of these features compared to STAT3-GOF patients (e.g., abscesses: 52.7% vs. 17.7%, P < 0.001; elevated IgE: 98.2% vs. 7.7%, P < 0.001) (17).