Haplotype analysis of CD209 rs4804803 and rs735239 demonstrated significant correlations with RA for the AG haplotype (OR = 5.07, 95% CI: 1.73–14.90, P = 0.003) and the GG haplotype (OR = 4.21, 95% CI: 1.33–13.31, P = 0.014), indicating a synergistic impact of these variations on disease susceptibility. Here, CD209 is linked to rheumatoid arthritis.