A comparison of DAS28-CRP scores with clinical and laboratory criteria among RA patients revealed that elevated disease activity grades were significantly correlated with arthritis affecting three or more joint regions, extended MS, increased VAS scores, elevated CRP, high ESR, and the administration of biologic therapy (P-values < 0.001), as well positive anti-CCP antibodies (P = 0.005) (Table 5). This evidence concerns the gene CRP and rheumatoid arthritis.