ADIPOQ and obesity due to melanocortin 4 receptor deficiency: Similarly, for adiponectin, HOMA‐IR showed significant indirect effects on obesity (β = −0.110, 95% CI [−0.160, −0.060]), abdominal obesity (β = −0.112, 95% CI [−0.161, −0.066]) and sarcopenic obesity (β = −0.103, 95% CI [−0.170, −0.040]), while the direct effects of adiponectin on these outcomes were not significant.