Increased collagen cross-linking (via LOXenzymes) and fiber alignment enhance mechanical tension, activatingsignaling pathways that drive tumor cell proliferation, invasion,and drug resistance., Laminin and fibrin support angiogenesisand provide a scaffold for migrating tumor cells.−,  Nevertheless,it is important to consider that ECM remodeling (ECM deposition anddegradation) is a continuous dynamic process that occurs throughouttumorigenesis. Here, LAMB2 is linked to neoplasm.