In our cohort, all systemic inflammatory indices—neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), pan-immune-inflammation value (PIV), and C-reactive protein to albumin ratio (CRP/Albumin)—demonstrated significant discriminatory capacity between pediatric Behçet’s disease (BD) patients and age-matched healthy controls. This evidence concerns the gene ALB and Behcet disease.