Given the limited data on pediatric Behçet’s disease (BD) and systemic inflammatory biomarkers, this study aimed to comprehensively characterize the clinical features of pediatric BD and evaluate the diagnostic performance of the neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), pan-immune-inflammation value (PIV), and C-reactive protein to albumin ratio (CAR) in predicting systemic, vascular, and neurological involvement. Here, CRP is linked to Behcet disease.