This pro‐oncogenic profile stands in sharp contrast to that of RING ligases such as RNF43, which has been reported to exert tumour‐suppressive effects in colorectal cancer,13, 14 underscoring substantial functional divergence within the RING E3 family and supporting RNF39 as an active driver of colorectal tumour progression rather than merely a correlative biomarker. Here, RNF39 is linked to neoplasm.