RNF39 mRNA expression was significantly upregulated in tumour tissues across multiple datasets: GSE23878 (tumour n = 35, normal n = 24), GSE32323 (tumour n = 17, normal n = 17) and GSE110225 (tumour n = 17, normal n = 17) (Figure 2C–E). This evidence concerns the gene RNF39 and neoplasm.