A complex relationship between anti-tumor B cells stimulating CD4+ T-cells and cytotoxic CD8+ T-cells causes increased secretion of cytokines such as CXC-Chemokine ligand 13 (CXCL13) which attracts more B-cells to ultimately form a mature TLS as can be seen in Fig. 1a [18]. This evidence concerns the gene CD4 and neoplasm.