Li-Fraumeni syndrome – a rare autosomal dominant syndrome defined by germline mutations in TP53 – confers a strong predisposition to broad spectrum of malignancies including breast cancer, soft tissue sarcomas, osteosarcomas, brain tumors, adrenocortical carcinomas, leukemia, and lymphoma [47, 48]. Here, TP53 is linked to Li-Fraumeni syndrome.