Given that focal adhesion kinase (FAK) acts upstream of YAP and regulates cancer stemness in multiple tumor contexts, and that dysadherin is known to activate integrin–FAK signaling,29–31 we explored whether the dysadherin–FAK–YAP axis drives the transcription of pluripotency genes in HCC. Here, FXYD5 is linked to hepatocellular carcinoma.