TP53 and sebaceous gland neoplasm: <h4>Aims</h4>This study aimed to investigate the clinical and histopathological features of sebaceous tumours of the genital area and their association with human papilloma virus (HPV) infection and mismatch repair (MMR) protein deficiency.<h4>Methods and results</h4>Ethical approval was obtained, haematoxylin and eosin (H&E)-stained sections were reviewed, and immunohistochemistry (IHC) for p16, p53, mismatch repair proteins and HPV RNA-in-situ hybridization or HPV genotyping were performed.