Moreover, we observed higher ADIPOR1 levels only in breast adipose tissue adjacent to the tumour in postmenopausal women with obesity and tumour size > 2.0 cm and clinical stage II/III (p = 0.019 and p = 0.025, respectively) versus postmenopausal women with a normal BMI. Here, ADIPOR1 is linked to obesity due to melanocortin 4 receptor deficiency.