ADIPOR1 and obesity due to melanocortin 4 receptor deficiency: Although this phenomenon was only present in breast tumour tissue and not in the adjacent breast adipose tissue of both postmenopausal women with normal BMI or with obesity, we hypothesized that it could be due to the autocrine effect of ADIPOR1 on breast tumour tissue, reducing tumour development or progression; however, is necessary to perform functional assays in order to probe this hypothesis.