Since our research group demonstrated by immunohistochemistry, that women with overweight or obesity had a lower expression of this adipokine and higher ADIPOR1 expression in breast cancer tissue [18], and that adiponectin plays a role in the TME of breast cancer; the objective of this study is to analyze the ADIPOQ and ADIPOR1 levels in fresh breast tumour tissue and adjacent adipose tissue of postmenopausal women with this cancer. The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.