High SMAPS was significantly associated with advanced disease stage (p < 0.0001), high tumour grade (p < 0.0001), micropapillary growth pattern (p < 0.0001), presence of lymphovascular invasion (p < 0.0001), high tumour budding grade (p < 0.0001), SARIFA positivity (p < 0.0001), and MMR proficient status (p < 0.0001). The gene discussed is MRC1; the disease is neoplasm.