Immature DR was significantly associated with colon tumour location (p = 0.003), advanced disease stage (p < 0.0001), high tumour grade (p < 0.0001), micropapillary growth pattern (p < 0.0001), presence of lymphovascular invasion (p < 0.0001), higher tumour budding grade (p < 0.0001), SARIFA positivity (p < 0.0001), and MMR proficient status (p = 0.003). This evidence concerns the gene MRC1 and neoplasm.