Most significantly, SHP1 inhibition by M029 phenocopies the antitumor effects seen in genotypic SHP1 knockout mice.[40] Thus, M029 inhibits syngeneic tumor growth and demonstrates robust intratumor target engagement as evidenced by the increased infiltration of NK cells and CD8+ T cells, improvements in their effector functions, and cytotoxicity of the infiltrated CD8+ T cells. This evidence concerns the gene CD8A and neoplasm.