In addition to its roles in cellular detoxification and lipogenesis through the stabilization of ACCα,7, 8, 9 Aldo‐keto reductase family 1 member B10 (AKR1B10) is markedly overexpressed in HCC tissues, including early‐stage and Alpha‐fetoprotein (AFP)‐negative cases, which supports its utility as an effective serum biomarker for diagnosis.10 The gene discussed is AKR1B10; the disease is hepatocellular carcinoma.