Transcriptionally, factors like cellular Myc proto‐oncogene (c‐Myc),55 hypoxia‐inducible factor 1 (HIF1),56 cAMP response element‐binding protein (CREB),57 and activator protein‐1 (AP‐1)58 regulate LDHA in various cancers. The gene discussed is HIF1A; the disease is cancer.