APOE and Alzheimer disease: In human Alzheimer’s cortex, human AD microglia (HAM) show a profile that only partially overlaps DAM: HAM display an enhanced aging signature with APOE upregulation and other disease-related programs, while many canonical DAM genes are not induced to the same extent; the data emphasize species and context differences and caution against equating mouse DAM with human AD microglia(Srinivasan et al. 2020).