Aβ Amyloid-β, DAM Disease-associated microglia, HAM Human AD microglia, DAMP Damage-associated molecular pattern, NF-κB Nuclear factor-κB, NLRP3 NOD-, LRR- and pyrin domain-containing protein 3, ASC Apoptosis-associated speck-like protein containing a CARD; CSF1R Colony-stimulating factor 1 receptor, CR3 Complement receptor 3, P2Y12/P2Y6 Purinergic receptors, SYK Spleen tyrosine kinase, TAM Tyro3/Axl/Mer receptor tyrosine kinases, Gas6 Growth-arrest–specific 6,  ProS Protein S, APOE Apolipoprotein E, CLU Clusterin. The gene discussed is APOE; the disease is Alzheimer disease.