This data was compared with K8 expression analysis in patients with CRC and in UALCAN database.<h4>Results</h4>K8<sup>flox/flox</sup>; CDX2P-CreER<sup>T2</sup> mice develop mild diarrhea and express reduced K8 and partner keratins in a mosaic pattern in the colonic epithelium. Here, KRT8 is linked to colorectal carcinoma.