CARM1 and breast carcinoma: This methylation activity drives tumor growth across multiplecancer types, including breast cancer, acute myeloid leukemia, gastriccancer, and small-cell lung cancer. Inbreast cancer, CARM1 mRNA shows consistent overexpression across allmolecular subtypes and disease stages relative to normal tissue., The oncogenic role of CARM1 is mediated through methylation of varioussubstrates that promote cancer progression.