The rs2910164 polymorphism-particularly genotypes carrying the G allele-together with a history of diabetes mellitus, dyslipidemia, smoking, NT-proBNP ≥ 300 pg/mL, a GRACE score >140, and a TIMI score >4, were identified as independent predictors of severe coronary stenosis. The gene discussed is NPPB; the disease is coronary stenosis.