NPPB and metabolic syndrome: In the multivariable analysis (Table 6), the following factors were identified as independent predictors of severe coronary stenosis: the CC + TC genotypes of rs2431697 (OR=0.10), the GG + CG genotypes of rs2910164 (OR=3.23), a history of diabetes mellitus (OR=5.14), dyslipidemia (OR=4.01), smoking (OR=5.16), NT-proBNP ≥ 300 pg/mL (OR=8.69), GRACE score >140 (OR=10.82), and TIMI score >4 (OR=6.50) (p < 0.05).