Multivariable analysis further demonstrated that the CC+TC genotypes of rs2431697, the GG+CG genotypes of rs2910164, a history of diabetes mellitus, dyslipidemia, smoking, NT-proBNP ≥ 300 pg/mL, GRACE score >140, and TIMI score >4 were independent predictors of severe coronary stenosis. This evidence concerns the gene NPPB and diabetes mellitus.