Figures 4 and 5 demonstrates that Pa-MACRO successfully identified several AD-related proteomic markers (ApoE, ApoB, CRP, MIG, and CgA) (Serrano-Pozo et al. 2021), imaging phenotypes including the right and left hippocampus, parahippocampus, and temporal pole regions (Frisoni et al. 2008, Fan et al. 2019, Geigenmüller et al. 2024). This evidence concerns the gene CRP and Alzheimer disease.