Figure 3 illustrates the weight of SNPs, where Pa-MACRO successfully identified several AD-risk loci, including the well-established rs429358 (APOE), rs4420638 (APOC1), rs56131196 (APOC1), and rs12721051 (APOC1) (Serrano-Pozo et al. 2021). Here, APOE is linked to Alzheimer disease.