ABCG2 and hyperuricemia: Similar results were obtained from all participants when hyperuricemia was defined as SUA of > 6.0 mg/dl in females: ABCG2 variants [PAF = 30.3%, 95% CI, 25.1–35.4, RR = 1.81 (95% CI, 1.63–2.02; P = 1.86 × 10–28)] had higher impacts than other typical environmental factors (Table 1 and Supplementary Fig. S1).