When hyperuricemia was defined as an SUA of > 6.0 mg/dl in females, ABCG2 variants also showed a significant and stronger effect [PAF = 31.8%, 95% CI, 18.5–45.0, RR = 1.87 (95% CI, 1.41–2.48; P = 1.04 × 10–5)] than overweight/obesity [PAF = 19.2%, 95% CI, 12.6–25.9, RR = 3.07 (95% CI, 2.31–4.09; P = 1.15 × 10–14)] and aging [PAF = 28.7%, 95% CI, 19.7–37.9, RR = 2.54 (95% CI, 1.95–3.30; P = 7.32 × 10–13)]. This evidence concerns the gene ABCG2 and obesity due to melanocortin 4 receptor deficiency.