ABCG2 and obesity due to melanocortin 4 receptor deficiency: In males, PAFs of ABCG2 variants still had a greater impact on progression of hyperuricemia [PAF = 30.2%, 95% CI, 24.9–35.3, RR = 1.81 (95% CI, 1.62–2.03; P = 9.72 × 10–27)] than overweight/obesity [PAF = 14.9%, 95% CI, 11.6–18.2, RR = 1.69 (95% CI, 1.52–1.87; P = 6.92 × 10–22)] or heavy drinking [PAF = 10.4%, 95% CI, 6.29–14.1, RR = 1.34 (95% CI, 1.20–1.49; P = 1.22 × 10–7)], although aging showed no significant RR (P = 0.241).