Males with a 25% loss of ABCG2 function, for example, show an effect equivalent to a 2.32-point increase in BMI, indicating that those with ABCG2 variants could set a numerical goal for reducing their body weight (e.g., 6.7 kg for a 170 cm-tall male) to prevent hyperuricemia by offsetting their genetic background. The gene discussed is ABCG2; the disease is hyperuricemia.