ABCG2 and obesity due to melanocortin 4 receptor deficiency: In females, ABCG2 variants [PAF = 33.1%, 95% CI, 2.91–62.5, RR = 1.93 (95% CI, 1.03–3.61; P = 0.0372)], overweight/obesity [PAF = 22.2%, 95% CI, 7.77–37.7, RR = 3.49 (95% CI, 1.87–6.52; P = 3.11 × 10–5)], and aging [PAF = 33.8%, 95% CI, 13.8–53.8, RR = 2.95 (95% CI, 1.65–5.26; P = 1.33 × 10–4)] had a significant effect, while heavy drinking did not (P = 0.232).