Another important aspect is the increased macrophage population on the placenta of women with obesity compared to pregnant women with normal weight, characterized by increased CD14+, CD68+, and CD11b+ markers (Challier et al. 2008), as well as increased gene expression of cytokines IL‐1, TNF‐α, IL‐6. The gene discussed is IL1B; the disease is obesity due to melanocortin 4 receptor deficiency.