According to the COSMIC and Cellosaurus databases, these cells harbour mutations in key CRC‐associated genes APC (p.E853*), BRAF (p.Val600Glu), PIK3CA (p.Pro449Thr), and TP53 (p.Arg273His), and are classified as CMS316, 17 (Table S1A,B). The gene discussed is PIK3CA; the disease is colorectal carcinoma.