Although CD45RA positivity has been proposed to distinguish LSCs from HSCs (Cloos et al., 2018; Boyer et al., 2018), CD45RA expression alone may not be sufficient to effectively distinguish LSCs from normal progenitors since AML blasts frequently lose CD90 expression (Holden et al., 1995; Inaba et al., 1997; Kozii et al., 1997). Here, THY1 is linked to acute myeloid leukemia.