NR1H3 and colorectal adenocarcinoma: Moreover, activation of liver X receptor alpha (LXRα) by LXR agonists T0901317 and GW3965, as well as activation of peroxisome proliferator-activated receptor delta (PPARδ) by the PPARδ agonist GW501516, has been shown to downregulate NPC1L1, thereby reducing cholesterol absorption in human colorectal adenocarcinoma Caco-2 cells and in a mouse model (Duval et al., 2006; Mathur et al., 2007).