Hyaluronic acid (HA) can bind to the cell membrane glycoprotein cluster of differentiation 44 (CD44), which is considered a cancer stemness marker, thereby transducing intracellular signaling and regulating a variety of biological activities of cancer cells (Dulal et al., 2018; Weng et al., 2022; Wold et al., 2024). The gene discussed is CD44; the disease is cancer.