Following stroke, pro-inflammatory cytokines including TNF-α and IL-1β (Cantarella et al., 2014; Ma et al., 2017) activate the Fas/FasL system, recruiting Fas-associated death domain (FADD) protein and procaspase-8 (Velier et al., 1999; Muhammad et al., 2018). Here, FADD is linked to Stroke.