In LUAD, NOTCH1 facilitates tumor development by inducing epithelial–mesenchymal transition (EMT) through both direct modulation of transcription factors such as SLUG, an E-box-binding TF that drives the EMT signaling by repressing the epithelial and polarity genes, and indirect interplay with other EMT-associated pathways within the tumor microenvironment (John and Sudandiradoss, 2024a). The gene discussed is NOTCH1; the disease is neoplasm.